What is Methoxetamine (MXE).?
Methoxetamine (abbreviated as MXE) is a novel psychoactive substance that is emerging on the Internet and induces dissociative effects and acute toxicity. MXE acts behaviourally as a typical dissociative anesthetic with stimulant and anxiogenic effects at lower doses, sedative/anesthetic effects at higher doses, and as a disruptor of sensorimotor gating. Its pharmacological effects have not yet been adequately investigated, but recently published articles shown, that MXE differentially affected motor activity, behavior, and emotional states in rats, depending on the dose tested. Methoxetamine acts mainly as N-methyl-D-aspartate (NMDA) receptor antagonist and a serotonin reuptake inhibitor.
Details about Methoxetamine
Like other psychoactive drugs, methoxetamine high is described as pleasurable.
And includes stimulant, relaxant, and dissociative effects.
But MXE has unpredictable and intense side effects.
Particularly with higher doses—that are extremely unpleasant both physically and psychologically.
This is sometimes called an m-hole.
Hospital reports show that, while people can recover from MXE drug toxicity.
This recovery period can require several days of hospitalization.
With treatment including detox medication, intravenous fluids, and respiratory support.
In addition, news stories have blamed several deaths on the consumption of the drug, MXE.
The hydrochloride salt of methoxetamine is a white, odorless crystalline powder at room temperature. A physical description of the freebase form could not be found in the readily accessible literature.
In research examining the pharmacological profile, data suggests that methoxetamine has an affinity for the N-methyl-D-aspartate (NMDA) receptor and acts as an antagonist.
Also, it is similar to the related ketamine but it has a longer duration of action than that of ketamine.
In addition similarly to ketamine, methoxetamine also involves dopamine and serotonin reuptake inhibition.
No studies have been performed examining the pharmacology and mode of action of methoxetamine in humans.
There are no published formal animal or human studies examining the pharmacokinetic properties of it.
How to take Methoxetamine?
Methoxetamine is a drug from the arylcyclohexylamine family of compounds.
Arylcyclohexylamines also include ketamine and PCP, which are two drugs that have been around for decades.
And which have been used for anesthesia in humans and animals.
In contrast, the MXE drug is a much more recently developed substance, which has been specifically used as a recreational drug.
MXE differs from ketamine on a molecular level.
Initial reports indicate that, despite its semi-legal status, it has a longer-lasting and more intense effect than ketamine.
There have not been any formal studies to demonstrate exactly how it works.
But it is assumed to work in the same way that ketamine does, that is, it affects the brain’s neurotransmitters by acting on their receptors.
One of the neurotransmitters thought to be affected is dopamine, which is associated with feelings of euphoria.
And has a role in many addictions, including those involving drugs.
Users report the rapid onset of action (10-20 minutes) following nasal insufflation, rectal, or intravenous/intramuscular administration.
The sublingual route is reported as less effective, with oral least effective.
Peak effects are reported to occur between 1-3 hours after exposure with a further duration of between three and six hours during which after-effects are experienced.
There are a few reports of effects lasting 24 hours; the half-life for clinical effects is three hours.
Methoxetamine users may experience pleasurable feelings of euphoria and enlightenment for up to 24 hours after using the drug 2. However, taking too much or having a bad reaction to MXE drug may lead to psychiatric, cognitive, neurological, and/or cardiovascular problems.
Despite legal restrictions placed on the recreational use of similar drugs, PCP and ketamine, there are currently no federal restrictions on the sale of MXE in the United States