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Diclazepam (also known as Chlorodiazepam) is a synthetic depressant substance of the benzodiazepine chemical class that produces effects similar to diazepams, such as anxiety suppression, disinhibition, anticonvulsant, hypnotic, muscle relaxing, and amnesia when administered.
- Diclazepam was first produced by Leo Sternbach and his team at Hoffman-La Roche in 60.
- In animal models, it has a potency of approximately ten times that of diazepam, of which it is a structural analog.
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- Therefore if accidentally ingested then immediate medical attention should be sought.
- Please ensure you add standard laboratory safety practices including using suitable skin, eye, and clothing protection.
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- Chlorodiazepam is basically a synthetic depressant substance that belongs to a chemical class of benzodiazepines and is related to diazepam in its properties.
- The benzodiazepines contain a basic benzene ring that is linked with a seven-membered diazepine ring, having two nitrogen constituents located at R1 and R4.
- Chemically, they have the same structure, as opposed to the R1 position, it is replaced by a methyl group.
- The benzodiazepine group is linked to a group of 2-chlorinated phenyl at R5, and also a chlorine group is attached at R7 of the benzyl ring.
- Chlorodiazepam also contains a ketone group that is formed by the double bonding of the oxygen group to the diazepine ring at the R2 position.
Solubility (Learn about Variance in Solubility)
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
- Ethanol: 10 mg/ml
- Background: Recently the number of new psychoactive substances has significantly increased, becoming popular among experienced users of designer drugs. A significant group includes benzodiazepine derivatives, which have not been introduced as medications but are abused by people experimenting with new and classical psychoactive substances.
- Case presentation: The aim of this paper was to present the case of clonazolam ingestion by a person who was not habituated to benzodiazepines. The intake caused only prolonged coma, decreased muscle tone, and deep tendon reflexes without any other concomitant toxicity and cardio-respiratory failure.
- Conclusions: Clonazolam concentrations in patient’s blood, measured three times were 0.077 mg/L, 0.015 mg/L, 0.009 mg/L after 4, 8 and 12 h, respectively. Clonazolam’s human toxicity has not been well established, so any case of poisoning should be closely monitored.
- Keywords: Blood confirmation; Clonazolam; New designer benzodiazepine.
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